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CARS makes it possible to image biochemically important molecules in living cells and organisms without labeling them with a dye. The contrast is produced by intrinsic vibrations of molecules in the specimen, avoiding the often complex fluorescence labeling procedure. It also is possible to prevent labels from influencing the behavior of the examined molecules, which permits measurements in cases where there is particularly high sensitivity to labeling with marker molecules.
The technique is said to complement and support fluorescence microscopy by contributing to a more in-depth understanding of biological and biochemical processes.
The technology, developed in the lab of Dr Xiaoliang Sunney Xie, Professor of Chemistry and Chemical Biology at Harvard, not only enables label-free imaging, but also the visualization of molecular labels that barely affect the properties of the marked biomolecules. Possible applications include pharmacokinetic examinations on the transport of active ingredients in biological tissues. The CARS technology also can potentially be used beyond cell biology, including for the development and testing of new active ingredients in the pharmaceutical industry, or for medical diagnostics.
DARPA Selects Goodrich to Continue Night Vision Imaging Development
The Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office (MTO) (Charlotte, N.C.) has selected Goodrich Corp. for the continued development of indium gallium arsenide (InGaAs) visible and shortwave infrared focal plane arrays for use in passive, night vision imaging systems.
According to Edward Hart, Vice President and General Manager of Goodrich's SUI team, "Our team has successfully completed the first phase of this contract and we now look forward to taking the technology to the next level. We welcome the opportunity to carry on this important initiative with DARPA and their innovative MTO group. The focus of this next phase of development will be to raise the resolution of the camera we developed in the first phase and make the imager more sensitive, allowing for better night vision capabilities."